Taking MK677 for an extended period of time, such as 2 years, can have significant impacts on your hormone levels and overall hormonal balance. MK677 works by stimulating the pituitary gland to release more growth hormone (GH). This increased GH production can lead to elevated levels of insulin-like growth factor 1 (IGF-1) as well. While this can promote muscle growth and other beneficial effects in the short-term, chronically high GH and IGF-1 levels over many months or years may start to have negative consequences. There is a risk of developing acromegaly, a condition characterized by enlargement of the hands, feet, and facial features due to excessive GH. Additionally, the constant stimulation of GH release could potentially lead to desensitization or downregulation of the ghrelin receptors that MK677 acts on, diminishing its effectiveness over time.
Another concern with long-term MK677 use is its potential impact on testosterone production. While MK677 does not directly affect testosterone levels, the elevated GH and IGF-1 can indirectly influence testosterone through complex hormonal feedback loops. Prolonged use may eventually lead to a decrease in your body's own natural testosterone generation. This could result in symptoms like low libido, fatigue, and muscle loss if testosterone levels fall too low. Careful monitoring of hormone panels would be essential to mitigate these risks with extended MK677 administration.